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7/09/2012  · Opioid abuse and dependence remains prevalent despite having multiple FDA-approved medications to help maintain abstinence. mirtazapine is an atypical antidepressant receiving attention for substance abuse pharmacotherapy, and its action includes alterations in monoaminergic transmission.

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20/11/2011  · 1. Introduction. Methamphetamine is a potent, highly abused psychostimulant, and relapse to drug-taking behavior in the abstinent methamphetamine abuser is alarmingly high.

AddictionMethamphetamine (MP) is a widely abused psychostimulant. There are currently no FDA approved pharmacotherapies for the MP addict. The antidepressant, mirtazapine (Mirt) is a high affinity antagonist at several monoaminergic receptors that are affected by MP.