Nucleus Accumbens Drug Addiction Hackensack Nj

A study was conducted to examine the hypothesis that the drug-reward trigger zone in the striatum, the medial olfactory tubercle and medial accumbens shell, receives dopaminergic projection from the drug-reward trigger zone in the ventral midbrain, the posterior VTA and central linear nucleus.

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The medial olfactory tubercle and medial accumbens shell (drug-reward trigger zones in the striatum) receive strong dopaminergic innervation from the posteromedial VTA and central linear nucleus (drug-reward trigger zones in the ventral midbrain), but with little innervation from anteromedial or lateral VTA. This arrangement of dopaminergic neurons can provide an explanation for the behavioral …

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2-Minute Neuroscience: Nucleus AccumbensMethamphetamine (MP) is a widely abused psychostimulant. There are currently no fda approved pharmacotherapies for the MP addict. The antidepressant, mirtazapine (Mirt) is a high affinity antagonist at several monoaminergic receptors that are affected by MP.

7/09/2012  · Opioid abuse and dependence remains prevalent despite having multiple FDA-approved medications to help maintain abstinence. Mirtazapine is an atypical antidepressant receiving attention for substance abuse pharmacotherapy, and its action includes alterations in monoaminergic transmission.

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